? 中心简介
必赢766net手机版分子医学研究中心(RCMM)属于必赢766net手机版，是由必赢766net手机版生化与分子生物学、细胞生物学、遗传学、病理学及免疫学等多个学科组成的交叉科研团队。
以分子细胞生物学为主要研究手段，从信号调控、细胞周期、细胞器等微观水平揭示包括恶性肿瘤、心血管、代谢、神经等重大疾病病因及病理改变的分子机制。中心由国家杰出青年基金获得者、必赢766net手机版副校长周天华教授领衔，逐渐形成了由万人计划、杰青、优青、省突出贡献中青年专家等教授组成的一系列学术梯队，承担了多项国家重大、重点研究计划。
? 中心特色
中心发展目标：建设一流的学科，培养一流的学生。
通过促进各PI间的科研合作，负责开展相关学科的各种科研活动及研究生学术培育工作，形成具有鲜明特色的研究群体，孵育高水平原创性的研究成果，培养高层次人才（包括PI和研究生）。
? 近一年代表性论文
l Bergeron LA, Besenbacher S, Zheng J, Li P, Bertelsen MF, Quintard B, Hoffman JI, Li Z, St Leger J, Shao C, Stiller J, Gilbert MTP, Schierup MH, Zhang G*. Evolution of the germline mutation rate across vertebrates. Nature. 2023 Mar;615(7951):285-291.
l Zhao Q, Chang H, Zheng J, Li P, Ye L, Pan R, Li D, Shao JZ, Zhao RC, Chen Y*. A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype. Signal Transduction And Targeted Therapy. 2023 Feb 27;8(1):86.
l Li Y, Zhou H, Liu P, Lv D, Shi Y, Tang B, Xu J, Zhong T, Xu W, Zhang J, Zhou J, Ying K, Zhao Y, Sun Y, Jiang Z, Cheng H, Zhang X*, Ke Y*. SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis. Journal of Clinical Investigation. 2023 Feb 15;133(4):e162870.
l Xiao P*, Hu Z, Lang J, Pan T, Mertens RT, Zhang H, Guo K, Shen M, Cheng H, Zhang X, Cao Q*, Ke Y*. Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit. Cellular & Molecular Immunology. 2023 Feb;20(2):119-130.
l Zhu X, Su Q, Xie H, Song L, Yang F, Zhang D, Wang B, Lin S, Huang J, Wu M, Liu T*. SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition. Nature Chemical Biology. 2023 Jan 12.
l Liu Z, Zhou X, Li Q, Shen Y, Zhou T, Liu X*. Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy. Acta Pharmaceutica Sinica B. 2023 Jan;13(1):327-343.
l Li S, Guo D, Sun Q, Zhang L, Cui Y, Liu M, Ma X, Liu Y, Cui W, Sun L, Teng L, Wang L, Lin A, Liu W, Zhuo W*, Zhou T*. MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages. Experimental and Molecular Medicine. 2023 Feb;55(2):457-469.
l Duan Y, Chen J, Meng X, Liu L, Shang K, Wu X, Wang Y, Huang Z, Liu H, Huang Y, Zhou C,Gao X, Wang Y, Sun J*. Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency. Molecular Therapy. 2022 Aug 31:S1525-0016(22)00506-8.
l Kuang W, Jin H, Yang F, et al. ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis. Cell Discovery. 2022;8(1):25. Published 2022 Mar 11.
l Wang RR, Qiu X, Pan R, et al. Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming. The Journal of Experimental Medicine 2022;219(7):e20211779.
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